molecular genomics


ecosystem impacts


global change


mutations 2 global change (m2gc)


This is a journal club / seminar series based at Carnegie & Stanford.

We aim to bring together molecular biologists, evolutionary geneticists, epidemiologists, ecologists, and climate scientists, and analyze frontier research to anticipate biological changes that can affect human or ecosystem health in a changing world, and brainstorm about potential solutions.


> Meeting flexibly either Tuesday, Wednesday or Thursday every week in the Carnegie library room (1st floor Carnegie Plant Biology historic building). To be up-to-date with rooms and times, access our m2gc calendar

> Join email list for announcements by sending a blank email to mutations2globalchange+subscribe@googlegroups.com or contact Moi.

> Moi Exposito-Alonso (moisesexpositoalonso@gmail.com)

SCHEDULE (updated as speakers/papers are confirmed)

  • Oct 17 2019 (1.30pm Carnegie Library room) we will have a videoconference with Ruth Shaw (U Minnesota) and discuss her paper (doi.org/10.1086/700565) on the limits of evolutionary prediction. This paper is also a great introduction to a century of mathematical population genetics.
  • Oct 24 2019 (9am Carnegie Global Ecology conference room) will feature a videoconference talk by Richard Neher (Basel Biozentrum) and we will discuss his nextrain.org platform (dx.doi.org/10.1093/bioinformatics/bty407). This is a virus evolution monitoring website feeding from global clinical datasets that uses phylogenetics to predict the next infectious strains.
  • [ Two weeks where we will join two CEHG.stanford.edu talks, one by Moi (Oct 30 12pm MSOB X303) on the latest paper of genomic predictions under climate change (dx.doi.org/10.1038/s41586-019-1520-9), and another from Chris Kyriazis (UCLA) (Nov 6 12pm Clark S360) in unintended maladaptation consequences of genetic restoration of threatened populations (dx.doi.org/10.1101/678524) ]
  • Nov 21 (11am Carnegie Seminar room) will feature a talk by Valentino Gantz (UC San Diego) on his co-invention, CRISPR gene drives (doi.org/10.1073/pnas.1521077112), to "control" species demographic and evolutionary fates.
  • Nov 26 2019 will feature a videoconference talk from Tom Crowther (ETH) and we will discuss the recent global restoration projection paper (dx.doi.org/10.1126/science.aax0848), which recently proposed 0.9 billion hectares of canopy cover could be restored to sink 205 gigatonnes of CO2.
  • Dec 5 2019 will feature a talk by Matthew Kling (UC Berkeley) and we will discuss the use of various quantitative large-scale models to understand the vulnerabilities of vegetation across the landscape (http://matthewkling.github.io/media/).
  • (TBC) we will discuss Laura Hayward's recent theory paper on polygenic adaptation after a sudden change in the environment (dx.doi.org/10.1101/792952).
  • (TBC) will feature a talk by Rachael Bay (UC Davis) on her paper projecting genomic vulnerability in a migratory bird (dx.doi.org/10.1126/science.aan4380).