genetic evolution & global change

Our questions and mission How mutations at the genetic level, subject to natural selection and drift, ultimately lead to ecological adaptation? Can we predict complex traits such as fitness and disease from an organism's genome and environment? Can we use novel molecular biology technology to understand the mechanisms of climate adaptation? Can we deploy new technologies to track and diagnose species and ecosystem declines and reliably guide sustainability policies?

Expertise and group research Our lab has experience in evolutionary molecular genetics, plant ecology, and computer science. Some of our work has dealt with understanding the rate at which new DNA mutations occur per generation, and what is the ecological relevance of genetic variation along the genome. We have pioneered the creation of geographic maps cataloging genetic variation of a species to anticipate the differential threats of climate change to its different populations. An important current project of the lab, co-coordinated with François Vasseur (CNRS) and Niek Scheepens (U. Frankfurt), is a distributed global evolution experiment, GrENE-net.org, which aims to test the evolvability of the plant Arabidopsis thaliana in many climates around the world. Using the same model, we are trying to direct adaptation in the lab using genome editing in plants grown under stressful conditions. We hope our efforts to fundamentally understand evolution of complex traits with genetic engineering tinkering will have not only an impact in ecology but also our understanding of complex human traits.

We strive for a diverse and inclusive lab and scientific community, and stand by the Black Lives Matter movement denouncing racism and xenophobia.

Open science We strive to make our research open to the public, posting papers on bioRxiv.org and making code and data available GitHub.com, Datadryad.org, or Figshare.com.

Affiliations and locations The lab is located at the Department of Plant Biology of the Carnegie Institution for Science, based in Stanford University, where we are also co-affiliated to Stanford's Department of Biology

Latest news

2021 02 10 A new paper by C Rellstab, B Dauphin and Moi just came out in Evolutionary Applications

2021 01 14 Lauren is giving a talk at NASA JPL on her satellite 2 species prediction model "deepbiosphere"

2021 01 11 Moi giving a talk in the Young Investigator Prize symposium at the American Naturalist 2021 Meeting #VirtualAsilomar2021

2020 12 7-11 Lauren speaking in Women in Machine Learning section @ NeurIPS and AGU presenting her work on Deep Learning of biodiversity with remote sensing and user identifications of species!

2020 11 10 The lab receives a grant from conservation non-profit ReviveRestore.org with Jeremy Yoder to study Joshua Tree genomes!

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2020 10 Our lab gets a NIH Director's High-Risk High-Reward grant!

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2020 08 Lab recruiting 4 postdocs! Check out the latest ad in our join us page!

2020 07 28 Our lab receives a large grant from the Department of Energy with a consortium of plant biologists!

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2020 03 15 Our Non-Additive Polygenic method with Nielsen in bioRxiv!

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2020 06 18 Collaborative paper with Monroe and Weigel labs in bioRxiv!

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2020 06 17 Moi received the Otto Hahn Medal from the Max Planck Society!

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2020 03 17 Moi named Forbes 30 under 30!

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2020 02 21 A commentary/re-analysis of Arabidopsis life history strategies just live in PNAS!

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2020 02 12 Moi receives the Young Investigator Prize of the American Society of Naturalists

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2020 01 30 Long publication times (another reason to bioRxive your paper)

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2019 08 27 Paper in Nature: "Natural selection on the Arabidopsis thaliana genome in present and future climates"

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2019 01 17 Preprints and Morale of PhD students

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The lab is supported by: