M O I L A B

genetic evolution & global change








Our questions and mission How mutations at the genetic level ultimately lead to ecological adaptation? Can we predict complex traits such as fitness and disease from an organism's genome and environment? Can we use novel molecular biology technology to understand the mechanisms of climate adaptation? Can we deploy new technologies to track and diagnose species and ecosystem declines and reliably guide sustainability policies?

Expertise and group research Our lab has experience in evolutionary molecular genetics, plant ecology, and computer science. Some of our work has dealt with understanding the rate at which new DNA mutations occur per generation, and what is the ecological relevance of genetic variation along the genome. We have pioneered the creation of geographic maps cataloging genetic variation of a species to anticipate the differential threats of climate change to its different populations. An important current project of the lab, co-coordinated with François Vasseur (CNRS) and Niek Scheepens (U. Tübingen), is a distributed global evolution experiment, GrENE-net.org, which aims to test the evolvability of the plant Arabidopsis thaliana in many climates around the world. Using the same model, we are trying to direct adaptation in the lab using genome editing in plants grown under stressful conditions. Finally, we are interested in applications of ecological genomic models to learn about complex human health traits.

Open science We strive to make our research open to the public, posting papers on bioRxiv.org and making code and data available GitHub.com, Datadryad.org, or Figshare.com.

Affiliations and locations The lab is located at the Department of Plant Biology of the Carnegie Institution for Science, based in Stanford University, where we are also co-affiliated to Stanford's Department of Biology

Latest news

2020 07 28 Our lab receives a large grant from the Department of Energy with a consortium of plant biologists!

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2020 03 15 Our Non-Additive Polygenic method with Nielsen in bioRxiv!

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2020 06 18 Collaborative paper with Monroe and Weigel labs in bioRxiv!

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2020 06 17 Moi received the Otto Hahn Medal from the Max Planck Society!

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2020 03 17 Moi named Forbes 30 under 30!

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2020 02 21 A commentary/re-analysis of Arabidopsis life history strategies just live in PNAS!

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2020 02 12 Moi receives the Young Investigator Prize of the American Society of Naturalists

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2020 01 30 Long publication times (another reason to bioRxive your paper)

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2020 01 13 First paper of the year, a perspectives on how to use evolutionary genetics concepts to improve predictions of species responses to climate change

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2019 08 27 Paper in Nature: "Natural selection on the Arabidopsis thaliana genome in present and future climates"

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2019 01 17 Preprints and Morale of PhD students

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